Pregnancy outcome of chorionic villus sampling on 260 couples with beta-thalassemia trait in north of Iran.
نویسندگان
چکیده
Chorionic villus sampling (CVS) is a new method and its true risk of fetal loss and complications is not still clearly determined. The objective of this study was to review the clinical pregnancy outcome of transabdominal CVS (TA-CVS) performed on women with minor beta thalassemia. TA-CVS performed on 300 women with a singleton pregnancy and we could follow 213 women until delivery. Data regarding induced legal abortion, spontaneous abortion, vaginal leakage, Vaginal bleeding and deformity of extremities (limb reduction) were obtained by questionnaire in five years. All CVS were performed by one operator. The mean gestation at time of CVS was 82.4 +/- 11.3 days. 79.2% of the procedures were made between 10-13 completed weeks and in other women (20.7%) TA-CVS was performed at 13-16 weeks. The majority (86.9%) required only one puncture. There were 47 pregnancy terminations because of fetal major beta thalassemia diagnosis (18 %). The rate of spontaneous abortion in our study was over ally (1.4%) and in two patients vaginal bleeding was noticed. We didn't find any vaginal leakage and limb reduction in our survey. TA-CVS is an accurate and safe procedure in experienced hands. It should be considered as one of the safe available procedures for women who require prenatal genetic diagnosis and wish to receive earlier diagnostic information for probable termination of pregnancy.
منابع مشابه
Chorionic villus sampling for the diagnosis of beta thalassemia in the first trimester of pregnancy in southwest Iran
Background and aim: Beta thalassemia is one of the most common hereditary disorders in Iran. The aim of this study is to improve the quality of life of couples with thalassemia and prenatal diagnosis of thalassemia major through the chorionic villus sampling technique. Methods: This prospective study was conducted on couples suffering from thalassemia minor who referred to Narges Genetics Labo...
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متن کاملFeasibility and safety of transabdominal chorionic villus sampling.
BACKGROUND Chorionic Villus Sampling (CVS) is the technique of choice for prenatal diagnosis prior to 12 weeks gestation. The objective of this study was to determine the feasibility, and pattern of complications following first trimester Trans-abdominal Chorionic Villus Sampling (TA-CVS). METHODS This was a descriptive study conducted in the Obstetrics and Gynaecology Department Military Hos...
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ورودعنوان ژورنال:
- Acta medica Iranica
دوره 48 3 شماره
صفحات -
تاریخ انتشار 2010